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Arteriosclerosis What is it? Arteriosclerosis is a chronic disease in which thickening, hardening, and loss of elasticity of the arterial walls that results in impaired blood circulation. It develops with aging, and in hypertension, diabetes, and other conditions. Give me an example! Heart disease and Arteriosclerosis often show up together during a medical check-up. A low-fat, low cholesterol diet will help prevent arteriosclerosis. Copyright ©2010, PCS Edventures, Inc. All Rights Reserved.